FIGURE

Fig. 4

ID

ZDB-FIG-180619-12

Publication

Gou et al., 2018 - sox2 and sox3 cooperate to regulate otic/epibranchial placode induction in zebrafish

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Fig. 4

Effect ofsox2-/-andsox3-/-on epibranchial ganglia. (A-D) Expression of phox2a at 36 hpf in a wild-type embryo (A), sox2 (B), sox3-/- (C) and sox2-/-; sox3-/- double mutant (D) embryo. Locations of the facial (f), glossopharyngeal (g), and vagal (v1 and v2) ganglia are indicated. Dorsal-lateral views with anterior to the left. (E) Quantitation of relative surface area of phox2a expression in individual epibranchial ganglia in control, sox2-/-, sox3-/- and sox2-/-; sox3-/- double mutant embryos. Data show means and standard deviations normalized to wild-type controls. Asterisks indicate statistically significant differences relative to controls (** P<0.01, *** P<0.001, Tukey's HSD test), or between non-control groups (bracket). (F, G) Dorsolateral views (anterior to left) showing expression of pax2a at 24 hpf in a control embryo (F) and sox2-/-; sox3-/- double mutant (G). Arrows indicate positions of epibranchial placodes. Scale bars, 50 µm.

Expression Data

Genes:	pax2a phox2a
Fish:	AB sox2^x50/x50 (AB) sox3^x52/x52 (AB) sox2^x50/x50; sox3^x52/x52 (AB)
Anatomical Terms:	epibranchial ganglion epibranchial placode facial ganglion glossopharyngeal ganglion vagal ganglion 1 vagal ganglion 2
Stage Range:	Prim-5 to Prim-25

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	sox2^x50/x50 (AB) sox3^x52/x52 (AB) sox2^x50/x50; sox3^x52/x52 (AB)
Observed In:	epibranchial placode facial ganglion glossopharyngeal ganglion vagal ganglion 1 vagal ganglion 2
Stage Range:	Prim-5 to Prim-25

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 435(1), Gou, Y., Guo, J., Maulding, K., Riley, B.B., sox2 and sox3 cooperate to regulate otic/epibranchial placode induction in zebrafish, 84-95, Copyright (2018) with permission from Elsevier. Full text @ Dev. Biol.