FIGURE

Fig. 5

ID

ZDB-FIG-180418-32

Publication

Gu et al., 2017 - Zebrafish Larvae Model of Dilated Cardiomyopathy Induced by Terfenadine

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Fig. 5

Terfenadine treatment induced apoptosis in cardiomyocytes. (A) H&E staining of longitudinal sections showed normal cardiomyocyte morphology of control (0.001% DMSO) zebrafish larvae. (B) Terfenadine (20 μM)-treated zebrafish larvae for 24 hours showed elongated and thin cardiomyocytes. (C) Detection of apoptotic cardiomyocytes by acridine orange staining in the control group. (D) Detection of apoptotic cardiomyocytes by acridine orange staining in terfenadine-treated zebrafish. Outlines of ventricles are shown with red lines. Apoptotic cells are indicated by red arrows. Scale bar=0.5 μm.

DMSO = dimethyl sulfoxide; dpf = days post fertilization; H&E = hematoxylin and eosin.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	twu34Tg
Condition:	chemical treatment by environment: Terfenadine
Observed In:	cardiac muscle cell myocardium apoptotic process
Stage:	Day 4

Phenotype Detail

Acknowledgments

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