FIGURE

Fig. 5

ID

ZDB-FIG-180411-2

Publication

Hammarsjö et al., 2017 - Novel KIAA0753 mutations extend the phenotype of skeletal ciliopathies

Other Figures

Fig. 5

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Fig. 5

Skeletal morphogenesis is affected in zebrafish larvae expressing truncated kiaa0753. (a) Heterozygous and wild-type carriers have a straight body; (b) Zebrafish expressing mutant Kiaa0753 in homozygosity present a ciliopathy-like phenotype characterized by a curved body, visible from 2 dpf; (c) Normal larvae head at 5 dpf; (d) disruption of cartilage structures were evident by 5 dpf, with mutant larvae presenting shorter head length along the anterior-posterior axis; (e,f) To quantify the phenotype, alcian blue staining was performed in wild-type and mutants, respectively; (g), and cartilage patterning was quantified according to scheme; (h) Statistical analysis showed that measurements 1–3 and 5–7 showed a significant difference between wild-type and mutant larvae (*p < 0.01) (mutant, n = 11; wild-type, n = 14).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	si:dkey-243i1.1^{sa22657/sa22657}
Observed In:	cranial cartilage cranial skeletal system development head trunk
Stage Range:	Long-pec to Day 5

Phenotype Detail

Acknowledgments

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