FIGURE

Fig. 1

ID

ZDB-FIG-180223-13

Publication

Eskova et al., 2017 - Gain-of-function mutations of mau/DrAqp3a influence zebrafish pigment pattern formation through the tissue environment

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Fig. 1

Mutations in aqp3a lead to undulating, broken stripes and short fins. (A-E) Comparison of wild type with mau mutants carrying the dominant alleles tVE1, tXGU1, tVBU1 and tWGU2. (F,H) The dominant mau phenotype is attenuated in heterozygous fish. (G,I) The loss-of-function mutant aqp3a−/−, generated in the background of aqp3atVE1/tVE1, has a wild-type phenotype in homozygous and heterozygous fish. (J) The aqp3atVE1/− phenotype is similar to that of aqp3atVE1/+. (K) Ratio of caudal fin length to standard body length (SL) in mau mutants. For each allele, seven to nine fish were measured. Mean±s.d. **P<0.01 for mutant versus wild type (one-way ANOVA followed by Tukey-Kramer multiple comparisons test). (L) Number of fin ray segments in the third ray of the caudal fin in wild-type and aqp3atVE1/tVE1 fish. n=8. Mean±s.d. ***P<0.0001 (unpaired t-test). (M) Length of fin ray segments in the third ray of the caudal fin in wild-type and aqp3atVE1/tVE1 fish. n=8. Mean±s.d. n.s., not significant (unpaired t-test).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	aqp3a^tVBU1/tVBU1 aqp3a^tVE1/tVE1 aqp3a^tWGU2/tWGU2 aqp3a^tXGU1/tXGU1 aqp3a^tVBU1/+ aqp3a^tVE1/+ aqp3a^tVE1/tVE1; aqp3a^zf1026/+ aqp3a^tVE1/tVE1; aqp3a^{zf1026/zf1026}
Observed In:	anal fin caudal fin dorsal fin lepidotrichium segment median fin melanophore stripe paired fin
Stage:	Adult

Phenotype Detail

Acknowledgments

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