FIGURE

Fig. 5

ID

ZDB-FIG-180202-13

Publication

McCammon et al., 2017 - The 16p11.2 homologs fam57ba and doc2a generate certain brain and body phenotypes

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Fig. 5

doc2a and fam57ba affect head size. A representative experiment from 4 experiments conducted is shown for each genotype. (A) Dorsal schematic of 12 dpf larval head, with panel letters indicating lines for the 4 measurements taken. (B–E) Fold-change relative to respective wild-type controls (blue bars) is shown for doc2a^+/− fam57ba^+/− (yellow bars, n = 19), fam57ba^−/− (purple bars, n = 19), fam57ba^+/− (green bars, n = 29), doc2a^+/− (orange bars, n = 26), and doc2a^−/− (pink bars, n = 36) larvae for inter-eye width, dorsal head length (D), hindbrain width, and forebrain width. (F) Lateral schematic of 12 dpf larval head, with panel letters indicating the four measurements taken. (G–J) Fold-change relative to respective wild-type controls for each genotype as described above for lateral head length (L), head height, eye width and eye height. (K,L) Live dorsal and lateral images of representative larvae for each genotype. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. Scale bar = 100 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	doc2a^wi721/wi721 tlcd3ba^wi720/wi720 doc2a^wi721/+; tlcd3ba^wi720/+
Observed In:	eye forebrain head hindbrain
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Hum. Mol. Genet.