ZFIN ID: ZDB-FIG-180201-7
Chen et al., 2017
- A multiplex preclinical model for adenoid cystic carcinoma of the salivary gland identifies regorafenib as a potential therapeutic drug.
7:11410 Full text @ Sci. Rep.
ACC11 cells show metastatic potential in an in-vivo zebrafish tumor metastasis model system. ACC11 cells (a), ACC11 PDX tissue (b), normal breast CRC cells (c), MCF7 cells (d), MDA-MB-231 cells (e), or A253 cells (f) labeled with CM-dil (red) were injected into the yolk sack of 2 day post fertilization (dpf) zebrafish embryos, and then imaged 3–7 days post injection. The vasculature is labeled green. White arrows indicate the area of injection in the yolk sac and red arrows indicate migrated ACC11 cells in the yolk sac in the main vessel (migration and metastasis), while red arrowheads indicate the cells that have extravasated from the main vessel into neighboring caudal hematopoietic tissue. Higher magnification for the tail region in panel (a) as an inset to show the extravasation of ACC11 cells into the neighboring tissue.
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Full text @ Sci. Rep.