ZFIN Figure: Zecca et al., 2015, Fig. 5

ZFIN ID: ZDB-FIG-180111-13

ZFIN ID: ZDB-FIG-180111-13

Zecca et al., 2015 - The Order and Place of Neuronal Differentiation Establish the Topography of Sensory Projections and the Entry Points within the Hindbrain. The Journal of neuroscience : the official journal of the Society for Neuroscience 35:7475-86 Full text @ J. Neurosci.

ADDITIONAL FIGURES

EXPRESSION / LABELING:

Genes:	crestin EGFP GFP
Fish:	nl1Tg zc7Tg cxcl12a^t30516/+; zf106Tg cxcl12a^{t30516/t30516}; zf106Tg cxcr4b^{t26035/t26035}; zf106Tg
Conditions:	chemical treatment by environment: leflunomide chemical treatment by environment: leflunomide, light ablation: anterior lateral line ganglion
Anatomical Terms:	anterior lateral line ganglion anterior lateral line ganglion anatomical region cranial neural crest cell neural crest cell posterior lateral line ganglion posterior lateral line ganglion anatomical region posterior lateral line ganglion neuron statoacoustic (VIII) ganglion statoacoustic (VIII) ganglion anatomical region statoacoustic (VIII) ganglion axon trigeminal ganglion trigeminal ganglion anatomical region trigeminal ganglion axon
Stage Range:	Prim-5 to High-pec

PHENOTYPE:

Fish:	nl1Tg zc7Tg cxcl12a^{t30516/t30516}; zf106Tg cxcr4b^{t26035/t26035}; zf106Tg
Conditions:	chemical treatment by environment: leflunomide chemical treatment by environment: leflunomide, light ablation: anterior lateral line ganglion
Observed In:	anterior lateral line ganglion axon guidance cranial ganglion cranial nerve VIII axon guidance cranial neural crest cell neural crest cell neural crest cell migration
Stage Range:	Prim-15 to High-pec

Fig. 5 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details

Gene	Fish	Conditions	Stage	Qualifier	Anatomy	Assay
crestin	zc7Tg	control	Prim-5		anterior lateral line ganglion anatomical region	ISH
			Prim-5		cranial neural crest cell	ISH
			Prim-5		posterior lateral line ganglion anatomical region	ISH
			Prim-5		statoacoustic (VIII) ganglion anatomical region	ISH
			Prim-5		trigeminal ganglion anatomical region	ISH
			Prim-15		neural crest cell	ISH
	zc7Tg	chemical treatment by environment: leflunomide	Prim-15	Not Detected	neural crest cell	ISH
EGFP	cxcl12a^t30516/+; zf106Tg	control	Prim-25		anterior lateral line ganglion	IFL
			Prim-25		statoacoustic (VIII) ganglion	IFL
			Prim-25		statoacoustic (VIII) ganglion axon	IFL
	cxcl12a^{t30516/t30516}; zf106Tg	control	Prim-25		anterior lateral line ganglion	IFL
			Prim-25		statoacoustic (VIII) ganglion	IFL
			Prim-25		statoacoustic (VIII) ganglion axon	IFL
	cxcr4b^{t26035/t26035}; zf106Tg	control	Prim-25		anterior lateral line ganglion	IFL
			Prim-25		statoacoustic (VIII) ganglion	IFL
			Prim-25		statoacoustic (VIII) ganglion axon	IFL
	nl1Tg	light ablation: anterior lateral line ganglion, light ablation: statoacoustic (VIII) ganglion, chemical treatment by environment: leflunomide	High-pec		posterior lateral line ganglion	IFL
			High-pec		posterior lateral line ganglion neuron	IFL
			High-pec		statoacoustic (VIII) ganglion	IFL
			High-pec		statoacoustic (VIII) ganglion axon	IFL
			High-pec		trigeminal ganglion	IFL
			High-pec		trigeminal ganglion axon	IFL
GFP	zc7Tg	control	Prim-5		anterior lateral line ganglion	IHC
			Prim-5		posterior lateral line ganglion	IHC
			Prim-5		statoacoustic (VIII) ganglion	IHC
			Prim-5		trigeminal ganglion	IHC
			Prim-15		anterior lateral line ganglion	IHC
			Prim-15		statoacoustic (VIII) ganglion	IHC
	zc7Tg	chemical treatment by environment: leflunomide	Prim-15		anterior lateral line ganglion	ISH
			Prim-15		anterior lateral line ganglion	IFL
			Prim-15		statoacoustic (VIII) ganglion	IFL
			Prim-15		statoacoustic (VIII) ganglion	ISH

Antibody Labeling Details No data available

Phenotype Details

Fish	Conditions	Stage	Phenotype
cxcl12a^{t30516/t30516}; zf106Tg	control	Prim-25	neural crest cell migration decreased occurrence, abnormal
cxcr4b^{t26035/t26035}; zf106Tg	control	Prim-25	neural crest cell migration decreased occurrence, abnormal
nl1Tg	light ablation: anterior lateral line ganglion, light ablation: statoacoustic (VIII) ganglion, chemical treatment by environment: leflunomide	High-pec	anterior lateral line ganglion axon guidance process quality, abnormal
		High-pec	cranial nerve VIII axon guidance process quality, abnormal
zc7Tg	chemical treatment by environment: leflunomide	Prim-15	cranial ganglion fused with cranial ganglion, abnormal
		Prim-15	cranial neural crest cell absent, abnormal
		Prim-15	neural crest cell crestin expression absent, abnormal

Full text @ J. Neurosci.