FIGURE

Fig. 5

ID

ZDB-FIG-171120-33

Publication

Askary et al., 2016 - Ancient origin of lubricated joints in bony vertebrates

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Fig. 5

Requirement of Prg4 gene function for fin joints of zebrafish.

(A) Schematic of pectoral fin joints. (B–E) SafraninO staining at 12 mpf shows abnormal joints between the ray (r) and scapula (sc) joint of the pectoral fin (B) in prg4b but not prg4a single mutants and prg4a; prg4b double mutants (DKO), and defects in the proximal radial (pr) and distal radial (dr) joint of the pectoral fin (C) in DKO. Defects include acellular matrix accumulation in the cavity (asterisks), synovial hyperplasia (arrowheads), and expanded deep chondrocytes (arrow). In contrast, the hyoid joint (D) and intervertebral discs (E) were normal in DKO. Phenotypes were consistently observed in three animals of each genotype. Scale bar 50 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	prg4a^el687/el687; prg4b^el594/el594
Observed In:	pectoral fin joint
Stage:	Adult

Phenotype Detail

Acknowledgments

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