FIGURE

Fig. 1

ID

ZDB-FIG-171020-11

Publication

Kirkwood et al., 2017 - d-Tubocurarine and Berbamine: Alkaloids That Are Permeant Blockers of the Hair Cell's Mechano-Electrical Transducer Channel and Protect from Aminoglycoside Toxicity

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Fig. 1

d-Tubocurarine and berbamine protect lateral line hair cells in zebrafish from gentamicin and neomycin induced damage. Zebrafish were treated with: (A,G,M,S) E3 alone (B) 6.25 μM neomycin, or (C–F) 25, 12.5, 6.25, or 3.1 μM of dTC plus 6.25 μM neomycin, (H) 10 μM gentamicin, (I–L) 25, 12.5, 6.25, or 3.1 μM of dTC plus 10 μM gentamicin, (N) 6.25 μM neomycin, (O–R) 25, 12.5, 6.25, or 3.1 μM of berbamine plus 6.25 μM neomycin, (T) 10 μM gentamicin, (U–X) 25, 12.5, 6.25, or 3.1 μM of berbamine plus 10 μM gentamicin. Neuromasts were pre-stained with 3 μM Yo-Pro1. n > 3 independent experiments with at least 3 fish per well. Images were obtained with a 40X objective. Scale bar = 25 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Cell. Neurosci.