FIGURE

Fig. 2

ID

ZDB-FIG-170825-19

Publication

Orr et al., 2016 - A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation

Other Figures

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Fig. 2

Electrocardiograms and whole hearts from WT transgenic and E17K transgenic zebrafish.

(a) WT transgenics exhibit a regular heart rate with electrocardiogram parameters typical for adult zebrafish. E17K transgenics display significantly slower sino-atrial activity and increased heart rate irregularity compared with controls. (b) Signal-averaged P-wave duration is prolonged in E17K transgenics, indicative of slower atrial conduction time. (c) Atrial area has been traced in isolated whole-WT transgenic and -E17K transgenic hearts (dotted lines), showing enlarged atrial chamber size in E17K transgenic.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	s977Tg
Observed In:	atrium heart contraction
Stage:	Adult

Phenotype Detail

Acknowledgments

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