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General Information
ZIRC
ZFIN ID: ZDB-FIG-170824-39
Sharma et al., 2015 - Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function. Nature communications   6:8391 Full text @ Nat. Commun.
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Genes:
Fish:
Knockdown Reagent:
Anatomical Terms:
Stage Range: Protruding-mouth to Day 6
PHENOTYPE:
Fish:
Knockdown Reagent:
Observed In:
Stage Range: Protruding-mouth to Days 7-13

Fig. 5 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
EGFP twu34Tg standard conditions Protruding-mouth heart IFL
Day 4 heart IFL
Day 5 heart IFL
twu34Tg + MO1-tmem65 standard conditions Protruding-mouth heart IFL
Day 4 heart IFL
Day 5 heart IFL
tmem65 WT standard conditions Protruding-mouth whole organism WB
Protruding-mouth to Day 6 heart IHC
Day 4 whole organism WB
Day 5 whole organism WB
Day 6 whole organism WB
WT + MO1-tmem65 standard conditions Day 4 whole organism WB
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
WT + MO1-tmem65 standard conditions Protruding-mouth heart morphology, abnormal
Protruding-mouth pericardium edematous, abnormal
Day 4 heart morphology, abnormal
Day 4 heart looping process quality, abnormal
Day 4 pericardium edematous, abnormal
Day 4 whole organism tmem65 expression decreased amount, abnormal
Day 5 heart morphology, abnormal
Day 5 pericardium edematous, abnormal
Day 6 heart morphology, abnormal
Day 6 pericardium edematous, abnormal
Days 7-13 heart morphology, abnormal
Days 7-13 pericardium edematous, abnormal
twu34Tg + MO1-tmem65 standard conditions Protruding-mouth heart morphology, abnormal
Protruding-mouth heart looping process quality, abnormal
Day 4 heart morphology, abnormal
Day 4 heart looping process quality, abnormal
Day 5 heart morphology, abnormal
Day 5 heart looping process quality, abnormal
Full text @ Nat. Commun.