FIGURE

Fig. S8

ID

ZDB-FIG-170619-30

Publication

Zhou et al., 2017 - Novel nesprin-1 mutations associated with dilated cardiomyopathy cause nuclear envelope disruption and defects in myogenesis

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Fig. S8

Human nesprin-1a2 WT induced heart development defects while mutants induce a less severe heart phenotype in zebrafish embryos . WISH monitoring expression of the myl7 gene at 48 hpf (A), the numbers (left in brackets) indicate the percentage of embryos displaying the phenotype represented in the picture shown, the numbers (right in brackets) are the total numbers counted of observed embryos. Human nesprin-1?2 WT caused a dilated heart phenotype (B-D), and both WT and mutants caused defects in heart looping when compared with uninjected shown (A,B) and abnormal anterior-posterior axis development (C, D) in the injected embryos when compared with uninjected and GFP expressing embryos. Approximately 36 to 62 embryos for each injection were counted; the representative picture (D) shows abnormal anterior-posterior axis development (black arrowhead) and dilated heart (red arrow) for the affected embryos.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Hum. Mol. Genet.