FIGURE

Fig. S1

ID

ZDB-FIG-170606-16

Publication

Lewis et al., 2017 - Cos2/Kif7 and OSM-3/Kif17 Regulate Onset of Outer Segment Development in Zebrafish Photoreceptors Through Distinct Mechanisms

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Fig. S1

osm-3/kif17 morphants have a reduction in both OS number and size. (Top) Wild-type embryos were injected with either a control morpholino (+Control MO) or osm-3/kif17 splice site junction morpholino (+Osm-3/Kif17 MO) and raised to 72hpf. Plastic histology reveals several evenly sized and uniformly distributed OS in the central retina of control morpholino-injected embryos (arrows), but OS are unevenly distributed and variable in size in osm-3/kif17 morpholino-injected embryos (arrows). (Bottom) Five biological replicates for each genotype were quantified as described above for the average OS area and density. osm-3/kif17 morpholino-injected embryos have approximately half as many OS, and OS that are approximately half the size of controls.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-kif17
Knockdown Reagent:	MO1-kif17
Observed In:	photoreceptor cell outer segment organization photoreceptor outer segment layer retinal photoreceptor layer photoreceptor outer segment
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 425(2), Lewis, T.R., Kundinger, S.R., Pavlovich, A.L., Bostrom, J.R., Link, B.A., Besharse, J.C., Cos2/Kif7 and OSM-3/Kif17 Regulate Onset of Outer Segment Development in Zebrafish Photoreceptors Through Distinct Mechanisms, 176-190, Copyright (2017) with permission from Elsevier. Full text @ Dev. Biol.