FIGURE

Fig. 6

ID

ZDB-FIG-170502-5

Publication

Zhang et al., 2017 - Critical Role for GAB2 in Neuroblastoma Pathogenesis through the Promotion of SHP2/MYCN Cooperation

Other Figures

All Figure Page

Back to All Figure Page

Fig. 6

Targeting MYCN with CBL0137 Is Effective against Neuroblastoma in MYCN;GFP Transgenic Fish

(A–D) EGFP-expressing tumors (arrowhead) in the MYCN;GFP compound transgenic fish, treated with vehicle (A and B) or CBL0137 (C and D) at days 1 or 15 of treatment. Scale bar, 1 mm.

(E) Differences in tumor volume in animals treated with vehicle or CBL0137 on day 15 versus day 1, as measured by the size of EGFP-positive tumor masses using ImageJ software. Mean values (horizontal bars) were compared by Welch t test (two-tailed).

(F) Histopathologic and immunohistochemical analyses of MYCN;GFP tumors treated with vehicle or CBL0137. Left: H&E-stained sagittal sections. Right: immunohistochemical staining with PCNA antibody. Scale bar, 50 μm.

(G) Immunoblot of lysates from MYCN;GFP tumors treated with vehicle or CBL0137. Total levels of Erk1/2 serve as loading controls.

Expression Data

Gene:	EGFP
Antibodies:	Ab1-ssrp1 Ab1-supt16h Ab5-pcna Ab6-mapk
Fish:	zdf16Tg (AB)
Condition:	chemical treatment by injection: CBL0137
Anatomical Term:	interrenal gland neuroblastoma
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	zdf16Tg (AB)
Condition:	chemical treatment by injection: CBL0137
Observed In:	interrenal gland neuroblastoma
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Cell Rep.