FIGURE

Fig. 3

ID

ZDB-FIG-170414-16

Publication

Palchaudhuri et al., 2015 - A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed

Other Figures

Fig. 3

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Fig. 3

Raptinal Exhibits Activity In Vivo

(A) Zebrafish embryos expressing secreted annexin V-YFP exhibit pronounced punctate YFP signal indicating phosphatidylserine externalization following 1.5 hr of treatment with 10 μM Raptinal.

(B) Quantification of apoptotic cells in Raptinal- versus DMSO-treated zebrafish under the conditions in (A). Data represent the mean ± SD (n = 5 and n = 7 embryos for Raptinal and DMSO, respectively; ^∗∗∗p value <0.001).

(C and D) Raptinal inhibits subcutaneous B16-F10 melanoma tumor growth in vivo as measured by tumor volume (^∗∗p value < 0.005) in (C) and tumor mass after tumor excision in (D) (^∗p value <0.05).

(E and F) Raptinal inhibits subcutaneous 4T1 breast cancer tumor growth in vivo as measured by tumor volume (^∗p value <0.05) in (E) and tumor mass after tumor excision (^∗p value <0.05) in (F).

Arrows in (C) and (E) indicate intraperitoneal Raptinal administration at 20 mg/kg once a day. Tumor images in (D) and (F) are representative of tumor size at the conclusion of the studies. Data in (C)–(F) represent the mean ± SEM (n = 7 mice/group). See also Figure S3.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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