FIGURE

Fig. 2

ID

ZDB-FIG-170317-6

Publication

Zheng et al., 2015 - Thiopeptide Antibiotics Exhibit a Dual Mode of Action against Intracellular Pathogens by Affecting Both Host and Microbe

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Fig. 2

Measurement of In Vivo Anti-infective Activities of Drugs

(A) M. marinum-infected zebrafish larvae (n = 10) in the presence of each test drug (3 ?M). Left: Fluorescence intensity of GFPmut3-expressing bacteria in larvae 5 days after treatment (^?p < 0.05, ^??p < 0.01, ^???p < 0.001; error bars represent the standard deviation). Right: larval survival during the treatment period.

(B) M. marinum-infected zebrafish adults (n = 20) treated once with each test drug (10 ?l of 5 ?M). Left: Pathological section of the infected area of randomly selected adults 10 days after treatment. The arrow indicates the existing or obliterated bacterial burden (red). Scale bar, 100 ?m. Right: Adult survival during the treatment period.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB
Conditions:	bacterial treatment by injection: Mycobacterium marinum M bacterial treatment by injection: Mycobacterium marinum M, chemical treatment by environment: thiostrepton bacterial treatment by injection: Mycobacterium marinum M, chemical treatment by injection: thiostrepton
Observed In:	whole organism
Stage Range:	Protruding-mouth to Adult

Phenotype Detail

Acknowledgments

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