FIGURE

Fig. S8

ID

ZDB-FIG-170220-14

Publication

Mayrhofer et al., 2017 - A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK/PI3K induced malignant growth

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Fig. S8

Ectopic YAP expression induces brain tumour development. A) Schematic representation of tumour induction through the injection of oncogenic constructs (green) into zic:Gal4 embryos. B) Stereo image of a tumour developed in zic:YAP_somatic. C) YAP target gene expression in zic:Gal4 control brains and zic:YAP_somatic tumours. D) Immunostaining for BrdU, GFAP and HU-C of zic:YAP_somatic tumours. E) Survival rate of zic:RAS_somatic (green dashed line) and zic:YAP_somatic (red dotted line) compared to zic:Gal4 (black solid line, black asterix). Data are represented as mean ± SD. Scale bars: B = 2 mm; G = 20 μm; *p-value<0.05.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dis. Model. Mech.