FIGURE

Fig. 3

ID

ZDB-FIG-170202-28

Publication

Lee et al., 2016 - Genetic inhibition of autophagy promotes p53 loss-of-heterozygosity and tumorigenesis

Other Figures

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Fig. 3

MPNSTs arising in Tg(mitfa:atg5K130R); tp53M214K/+ fish express sox10. A.-B. Representative photomicrographs of gross macroscopic appearance of tumors A. and hematoxylin and eosin (H&E) stained microscopic sections of corresponding tumors B. in Tg(mitfa:atg5K130R); tp53M214K/+ fish. MPNST, malignant peripheral nerve sheath tumor. Scale bars, 50 μm. See Table 1 for details of numbers of fish with each tumor type. C. Representative confocal images to detect GFP expression, H&E staining, and anti-GFP immunoperoxidase staining of an MPNST from a Tg(mitfa:atg5K130R); Tg(sox10:EGFP); tp53M214K/+ fish (top) and an MPNST from a GFP-negative control Tg(mitfa:atg5K130R); tp53M214K/+ (bottom). Liver is shown for the anti-GFP immunoperoxidase staining as a representative non-tumor tissue (right panels). Scale bars, 100 µm.

Expression Data

Gene:	EGFP
Fish:	tp53^zdf1/+; ba2Tg; sw51Tg (AB)
Anatomical Terms:	anatomical structure nerve sheath tumor anatomical structure neurofibrosarcoma
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tp53^zdf1/+; ba2Tg; sw51Tg (AB)
Observed In:	whole organism neurofibrosarcoma
Stage:	Adult

Phenotype Detail

Acknowledgments

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