Signaling through Flt4 Y1226/7 is dispensable for normal lymphatic function. (A-D) Transmitted light images of live zebrafish larvae at 10 dpf (A,D) or 5 dpf (B,C). Genotype is indicated in each panel. Lateral views, anterior to the left, dorsal is up. Arrows denote edema surrounding the intestinal tract and heart, arrowheads indicate edema surrounding the eyes. (E) Proportion and numbers of larvae of the indicated genotype exhibiting edema at 5 dpf for vegfcum18 and flt4um131 or 10 dpf for flt4Y1226/7Δ. ***P<0.001.