FIGURE

Fig. S3

ID

ZDB-FIG-161122-44

Publication

Mouti et al., 2016 - Minimal contribution of ERK1/2-MAPK signalling towards the maintenance of oncogenic GNAQQ209P-driven uveal melanomas in zebrafish

Other Figures

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Fig. S3

Choroidal hyperplasia is evident in pigmentation-rescued Tg (mitfa:GNAQ^Q209P;slc24a5^-/-) zebrafish. A-D. H&E staining of transverse sections of formalin-fixed and paraffin-embedded eye tissues of a 5-month-old adult zebrafish. (A) Wild-type demonstrating different structures of the zebrafish retina as indicated. (B) Golden mutant: note the hypopigmented RPE and structurally normal choroid. (C, D) Tg (mitfa:GNAQ^Q209P;slc24a5^-/-): note here benign hyperplastic choroidal lesions (black arrowheads) developing beneath pigmentation-rescued RPE. E. A representative example of H&E stained transverse section illustrating thickened and heavily pigmented choroidal melanocyte layer before melanin bleaching. F. Multiple cellular layers of thickened choroid, as revealed by multiple nuclei (blue; counterstained with hematoxylin) after melanin bleaching. Abbreviations: RPE, retinal pigmented epithelium. Scale bar lengths, as indicated.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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