FIGURE

Fig. 2

ID

ZDB-FIG-161027-2

Publication

Huang et al., 2016 - Sox9b is a mediator of retinoic acid signaling restricting endocrine progenitor differentiation

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Fig. 2

RA and Notch signaling have separate effects on CAC differentiation. (A-D) Images of 5 dpf cftr:cftr-gfp dissected foregut following drug treatment. GFP signal is abolished in larvae treated with DAPT (C) and RA+DAPT (D). (E-H) Images of anti-2F11 staining in 5 dpf dissected foregut following drug treatment. Expression of the ductal epithelial marker 2F11 is maintained under all treatment conditions. Larvae were incubated from 3 to 5 dpf with DMSO (A, E), RA (B, F), DAPT (C, G), or RA+DAPT (D, H). White dashed lines outline pancreata. Scale bar=100 µm.

Expression Data

Gene:	GFP
Antibody:	Ab-2F11
Fish:	WT pd1041Tg
Conditions:	chemical treatment by environment: DAPT chemical treatment by environment: all-trans-retinoic acid chemical treatment by environment: all-trans-retinoic acid
Anatomical Terms:	pancreas pancreatic centroacinar cell pancreatic ductal cell
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	pd1041Tg
Conditions:	chemical treatment by environment: DAPT chemical treatment by environment: all-trans-retinoic acid
Observed In:	pancreas pancreatic centroacinar cell
Stage:	Day 5

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 418(1), Huang, W., Beer, R.L., Delaspre, F., Wang, G., Edelman, H.E., Park, H., Azuma, M., Parsons, M.J., Sox9b is a mediator of retinoic acid signaling restricting endocrine progenitor differentiation, 28-39, Copyright (2016) with permission from Elsevier. Full text @ Dev. Biol.