FIGURE

Fig. 1

ID

ZDB-FIG-160714-11

Publication

Kawauchi et al., 2016 - Using mouse and zebrafish models to understand the etiology of developmental defects in Cornelia de Lange Syndrome

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Fig. 1

Nipbl-deficient mutant animals show growth abnormalities. (A) Nipbl^+/- mouse is markedly smaller than wildtype (+/+) sibling at 4 weeks of age. (B) Nipbl a+b morpholino (MO) co-injected zebrafish larvae (nipbl a/b morphants) resemble uninjected and mixed MO controls at 18.5 hr post-fertilization (hpf), but show marked circulatory defects, pericardial edema (asterisk) and tail defects (arrowheads) by 34 hpf. Scale bar = 100 �m. (C) Structural comparison of NIPBL orthologues among different species. H.s., Homo sapiens, 2,804 amino acids (aa).; M.m., Mus musculus, 2,798 aa; D.r. (a), Danio rerio, form a, 2,876 aa; D.r. (b), form b, 2,381 aa; D.m., Drosophila melanogaster, 2,077 aa; S.c., Saccharomyces cerevisiae, 1,493 aa. Numbers indicate percent amino acid sequence identity compared to human NIPBL. Adapted from [Kawauchi et al., 2009; Muto et al., 2011].

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Am J Med Genet C Semin Med Genet