ZFIN ID: ZDB-FIG-160511-15
Liu et al., 2016 - A secreted WNT-ligand-binding domain of FZD5 generated by a frameshift mutation causes autosomal dominant coloboma. Human molecular genetics   25(7):1382-91 Full text @ Hum. Mol. Genet.
EXPRESSION / LABELING:
Gene:
Fish:
Knockdown Reagent:
Anatomical Terms:
Stage: Prim-5
PHENOTYPE:
Fish:
Knockdown Reagent:
Observed In:
Stage Range: Prim-5 to Protruding-mouth

Fig. 2 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
GFP w25Tg control Prim-5 optic cup ISH
Prim-5 solid lens vesicle ISH
w25Tg + MO3-fzd5 standard conditions Prim-5 optic cup ISH
Prim-5 solid lens vesicle ISH
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
AB + MO3-fzd5 standard conditions Protruding-mouth eye decreased size, abnormal
Protruding-mouth eye perforate, abnormal
Protruding-mouth optic fissure closure incomplete, abnormal
w25Tg + MO3-fzd5 standard conditions Prim-5 canonical Wnt signaling pathway disrupted, abnormal
Prim-5 optic cup GFP expression increased amount, abnormal
Prim-5 solid lens vesicle GFP expression decreased amount, abnormal
Full text @ Hum. Mol. Genet.