FIGURE
Fig. S4
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- ZDB-FIG-160426-15
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- Kent et al., 2016 - UHRF1 regulation of Dnmt1 is required for pre-gastrula zebrafish development
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Fig. S4
5-AZA treatment does not phenocopy uhrf1 morphants or UHRF1 over-expressing embryos. Embryos were exposed to 70 µM or 100 µM 5- AZA from 0.5 to 6 hpf. (A) Developmental progression of uninjected wild-type embryos and embryos exposed to 70 µM 5-AZA. Scale bar = 500 micrometers. (B) Quantification of sphere stage arrest with the number of embryos, the number of biological replicates, and proportion of embryos displaying sphere stage arrest are indicated. Statistical significance was calculated using Fisher’s exact test (p < 0.05). Asterisk indicates significance. (C) Kaplan-Meier survival curve. |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
Acknowledgments
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Reprinted from Developmental Biology, 412(1), Kent, B., Magnani, E., Walsh, M.J., Sadler, K.C., UHRF1 regulation of Dnmt1 is required for pre-gastrula zebrafish development, 99-113, Copyright (2016) with permission from Elsevier. Full text @ Dev. Biol.