FIGURE

Fig. 4

ID

ZDB-FIG-160323-5

Publication

Liu et al., 2015 - Grhl1 deficiency affects inner ear development in zebrafish

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Fig. 4

Hearing disability in Hearing disability in grhl1 knockdown zebrafish which could be rescued by DSG1 mRNA. (A) Poorly organized desmosomes (arrows) in the MO group could be rescued by DSG1 mRNA. (B) Dsg1 rescued decreasing numbers of neuromasts in the lateral line. (C) Examples of C-shaped startle responses of different larval groups in response to a 500 Hz sound of 10 ms duration. Typical escape response of wild-type larva initiated 10 ms after stimulation. (D) Average C-startle response probability after sound stimulation. At least 40 larvae were tested for each group. Bar, 1 mm. knockdown zebrafish which could be rescued by DSG1 mRNA. (A) Poorly organized desmosomes (arrows) in the MO group could be rescued by DSG1 mRNA. (B) Dsg1 rescued decreasing numbers of neuromasts in the lateral line. (C) Examples of C-shaped startle responses of different larval groups in response to a 500 Hz sound of 10 ms duration. Typical escape response of wild-type larva initiated 10 ms after stimulation. (D) Average C-startle response probability after sound stimulation. At least 40 larvae were tested for each group. Bar, 1 µm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-grhl1
Knockdown Reagent:	MO1-grhl1
Observed In:	neuromast hair cell desmosome sensory perception of sound startle response
Stage:	Day 5

Phenotype Detail

Acknowledgments

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