FIGURE
Fig. S14
- ID
- ZDB-FIG-160304-39
- Publication
- Ye et al., 2016 - An insulin signaling feedback loop regulates pancreas progenitor cell differentiation during islet development and regeneration
- Other Figures
- All Figure Page
- Back to All Figure Page
Fig. S14
Transplanted endoderm-committed blastomeres (ECBs) can differentiate into pancreatic endocrine cells in β cell ablated host larvae. (A-C′) Merged and single channel confocal planes of chimeras composed of Tg(sox17:GFP) ECBs transplanted into β cell-ablated host larvae, shown at 2 days post transplantation (dpt)/6 dpf. Chimeras were immunostained for GFP (green), Insulin (red), Glucagon (white), and DAPI (blue). (A,B) Control donor ECBs, and (C) dnIRS2-GFP mRNA-injected ECBs. With insulin signaling blockade, insulin+ β cell generation was increased in donor ECBs, while Glucagon+ α cell generation was decreased. |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and
ZFIN has permission only to display this image to its users.
Additional permissions should be obtained from the applicable author or publisher of the image.
Reprinted from Developmental Biology, 409(2), Ye, L., Robertson, M.A., Mastracci, T.L., Anderson, R.M., An insulin signaling feedback loop regulates pancreas progenitor cell differentiation during islet development and regeneration, 354-69, Copyright (2016) with permission from Elsevier. Full text @ Dev. Biol.