FIGURE

Fig. 6

ID

ZDB-FIG-151123-3

Publication

Liang et al., 2015 - Kaempferol Identified by Zebrafish Assay and Fine Fractionations Strategy from Dysosma versipellis Inhibits Angiogenesis through VEGF and FGF Pathways

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Fig. 6

Kaempferol blocked PI3K/Akt and p38 MAPK in vitro and had a synergistic effect with PTK787/SU5402 on VEGF and FGF pathways in vivo.

(A) different concentrations of kaempferol were added to HUVECs for 24 hours or 48 hours and analysed for Erk1/2, p38, Akt phosphorylation and VEGFR2 expression by Western blotting. CTL-control. (B) a synergistic effect of kaempferol with VEGF inhibitor PTK787 or FGF inhibitor SU5402 was observed. Compounds were added at 6 hpf and pictured at 52 hpf, anterior is to left and dorsal is to top. Affected ratio is showed in the lower right corner. Full-length blots are presented in Supplementary Fig. S2.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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