Fig. 4
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- ZDB-FIG-151113-3
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- Xu et al., 2015 - Temporal-Spatial Resolution Fate Mapping Reveals Distinct Origins for Embryonic and Adult Microglia in Zebrafish
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The Microglia in the Eye Exhibit Distinct Colonization and Composition Profile to the Microglia in the CNS (A) The RBI- but not VDA- and PBI-region-derived cells (coro1a-GFP+ cells) constitute the major population of microglia (Lcp1+ cells) in the eyes (indicated by dashed lines) of 4-dpf zebrafish. White arrows indicate coro1a-GFP+ microglia in the eyes. (B) The RBI- and VDA- but not PBI-region-derived cells (coro1a-GFP+ cells) constitute the major population of microglia (Lcp1+ cells) in the 3-month adult zebrafish eye. White arrows indicate the coro1a-GFP+ microglia in the eyes. (C) Quantification of the contribution of the RBI-, VDA-, and PBI-region-derived microglia in the developing and adult zebrafish eyes. For the RBI-labeled 4-dpf, 15-dpf, 1.5-month, 3-month, and 1-year adult fish, n = 8, 8, 5, 8, and 10, respectively; for the VDA-region-labeled 4-dpf, 15-dpf, 1.5-month, 3-month, and 1-year adult fish, n = 5, 6, 5, 8, and 9, respectively; for the PBI-labeled 4-dpf, 15-dpf, 1.5-month, and 3-month adult fish, n = 7, 6, 7, and 8, respectively. Error bars represent mean ± SEM. p < 0.05; p < 0.01; p < 0.001. |
Reprinted from Developmental Cell, 34, Xu, J., Zhu, L., He, S., Wu, Y., Jin, W., Yu, T., Qu, J.Y., Wen, Z., Temporal-Spatial Resolution Fate Mapping Reveals Distinct Origins for Embryonic and Adult Microglia in Zebrafish, 632-641, Copyright (2015) with permission from Elsevier. Full text @ Dev. Cell