FIGURE

Fig. 6

ID

ZDB-FIG-150922-11

Publication

Li et al., 2015 - Integrative Analysis of Circadian Transcriptome and Metabolic Network Reveals the Role of De Novo Purine Synthesis in Circadian Control of Cell Cycle

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Fig. 6

impdh2 mediates the circadian control of cell cycle.

(A) The BrdU staining in 5 dpf larvae represents the daily rhythm of S phase in cell cycle under LD conditions. (B) The amplitude of the S phase rhythm was attenuated when the larvae were treated with MPA. The effect of MPA was rescued when guanosine was added to MPA-treated larvae. The inhibitory effect of MPA on the S phase rhythm was in a dose-dependent manner and saturated at 10μM concentration. (C) The amplitude of the S phase rhythm decreased significantly in impdh2 morphants. At least three larvae were measured at each data point. Error bars represent the standard error of mean (SEM) among independent biological replicates. Scale bars, 200μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-impdh2
Knockdown Reagent:	MO1-impdh2
Observed In:	cell cycle circadian rhythm
Stage:	Day 5

Phenotype Detail

Acknowledgments

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