Fig. 5
- ID
- ZDB-FIG-150629-4
- Publication
- Blackburn et al., 2014 - Clonal evolution enhances leukemia-propagating cell frequency in T cell acute lymphoblastic leukemia through Akt/mTORC1 pathway activation
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The Akt Pathway Increases LPC Frequency through Downstream Activation of mTORC1 and Shortens Latency by Augmenting Myc Stability (A) Representative images of zebrafish that were transplanted with 25 LPCs from T-ALL expressing GFP and the indicated constructs (three T-ALL per genotype, n = 35 animals transplanted per primary leukemia) at 28 days posttransplantation. (B) Kaplan-Meier analyses of time to T-ALL regrowth for each genotype and compared to Myc alone expressing T-ALL. Denotes a significant difference in latency of p < 0.0001. Indicates a significant difference in latency of p = 0.003. (C) EDU analysis of transgenic T-ALL. Each datum point represents the percent EDU-positive cells for one T-ALL. §Represents a significant difference of p < 0.0001. §§Denotes a significant difference of p = 0.004, when compared to Myc alone expressing T-ALL. NS, no significant difference. (D) Graph showing LPC frequency within each transgenic group. Each point represents data for one primary T-ALL. #Denotes a significant difference in LPC frequency of p < 0.0001. ##Indicates a significant difference in LPC frequency of p = 0.0025 when compared to Myc alone expressing T-ALL. NS, no significant difference. (E) Western blot analysis. See also Figure S5 and Table S4. |
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| Stage: | Adult |
Reprinted from Cancer Cell, 25, Blackburn, J.S., Liu, S., Wilder, J.L., Dobrinski, K.P., Lobbardi, R., Moore, F.E., Martinez, S.A., Chen, E.Y., Lee, C., Langenau, D.M., Clonal evolution enhances leukemia-propagating cell frequency in T cell acute lymphoblastic leukemia through Akt/mTORC1 pathway activation, 366-78, Copyright (2014) with permission from Elsevier. Full text @ Cancer Cell