FIGURE

Fig. 4

ID

ZDB-FIG-150625-1

Publication

Wolman et al., 2015 - A Genome-wide Screen Identifies PAPP-AA-Mediated IGFR Signaling as a Novel Regulator of Habituation Learning

Other Figures

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Fig. 4

pappaa^p170 Mutants Show Reduced Swim Bladder Inflation, Habituation, and Survival

(A) pappaa^p170 mutants appear grossly normal at 5 dpf, with exception of some showing an uninflated swim bladder.

(B) pappaa^p170 larvae show startle habituation deficit at 5 and 12 dpf.

(C) Kaplan-Meier survival curve shows reduced viability in pappaa^p170 mutants. *p < 0.001, one-way ANOVA (with Bonferonni correction) versus pappaa^+/+, **p < 0.0001 Mantel-Cox test versus wild-type siblings. N = number of larvae shown within bars (B) or in legend (C). Error bars indicate SEM.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	pappaa^p170/p170
Observed In:	habituation swim bladder inflation whole organism
Stage Range:	Day 5 to Days 14-20

Phenotype Detail

Acknowledgments

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