FIGURE
Fig. 7
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- ZDB-FIG-150609-6
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- Erickson et al., 2015 - A 190 base pair, TGF-β responsive tooth and fin enhancer is required for stickleback Bmp6 expression
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Fig. 7
Treatment with TGFβ inhibitor SB431542 reduces Bmp6 expression. (A-D) Sticklebacks were treated with 100 µM SB431542 or vehicle control from 2 to 5 dpf or for 5 days post-hatching, and Bmp6 expression was assayed by in situ hybridization. Drug treatment severely reduced Bmp6 expression in fins (A, B) and also reduced Bmp6 expression in tooth epithelia (C, D). Likewise, GFP driven by the Bmp6 locus in the reporter BAC was also reduced in fins (arrowheads in E, F) and teeth (G, H) after SB431542 treatment. Scale bars=100 µm. |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
Acknowledgments
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Reprinted from Developmental Biology, 401(2), Erickson, P.A., Cleves, P.A., Ellis, N.A., Schwalbach, K.T., Hart, J.C., Miller, C.T., A 190 base pair, TGF-β responsive tooth and fin enhancer is required for stickleback Bmp6 expression, 310-23, Copyright (2015) with permission from Elsevier. Full text @ Dev. Biol.