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Fig. 1

ID

ZDB-FIG-150427-34

Publication

Karanth et al., 2013 - Polyunsaturated fatty acyl-coenzyme As are inhibitors of cholesterol biosynthesis in zebrafish and mice

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Fig. 1

Ketogenic diets trigger hepatic steatosis in slc16a6a mutants. At 30 dpf, wild-type (WT) and slc16a6a mutant (MUT) zebrafish juveniles were placed on ketogenic diets (K4 and K12; supplementary material Table S1). (A) Livers were harvested and analyzed after 15, 30 or 45 days on diets. MUT livers showed progressive steatosis during the study, whereas WT did not. (B) Transmission electron microscopy of liver sections; cytoplasmic lipid droplets (ld), nuclei (n), glycogen granules (g). Scale bars: 1 µm. (C–F) Fasting blood glucose, triacylglycerol, cholesterol (total) and free fatty acids did not differ among the cohorts placed on either ketogenic diet (K4 or K12). All data are mean ± s.d.

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