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Fig. S9

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ZDB-FIG-150427-22

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Nakayama et al., 2013 - Gbx2 functions as a transcriptional repressor to regulate the specification and morphogenesis of the mid-hindbrain junction in a dosage- and stage-dependent manner

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Fig. S9

Overexpression of gbx2 and en-gbx2 elicited dorsalization of embryos. Embryos were injected with mRNA for egfp (100 pg/embryo), gbx2 (30 pg/embryo), en-gbx2 (30 pg/embryo), or vp-gbx2 (100 pg/embryo). Lateral views with dorsal to the right and anterior to the top. (a–d) Bud-stage embryos with percentages showing extended morphology. (e–l) Expression of dorsoventral marker genes in 60%-epiboly embryos injected with gbx2-related genes. Ventral expression of eve1 was reduced by gbx2 and en-gbx2, whereas expanded by vp-gbx2. Dorsal expression of chd showed opposite responses to the same genes. Percentages show the embryos with the phenotypes shown in respective panels. Scale bars, 200 µm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Mechanisms of Development, 130(11-12), Nakayama, Y., Kikuta, H., Kanai, M., Yoshikawa, K., Kawamura, A., Kobayashi, K., Wang, Z., Khan, A., Kawakami, K., and Yamasu, K., Gbx2 functions as a transcriptional repressor to regulate the specification and morphogenesis of the mid-hindbrain junction in a dosage- and stage-dependent manner, 532-52, Copyright (2013) with permission from Elsevier. Full text @ Mech. Dev.