FIGURE

Fig. 5

ID

ZDB-FIG-140807-29

Publication

Koole et al., 2014 - Mosaic analysis and tumor induction in zebrafish by microsatellite instability-mediated stochastic gene expression

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Fig. 5

Sporadic tumor induction. (A) Merged images show the difference between the expression of UAS:EGFP-HRAS-G12V in a tissue-wide (left) and stochastic (right) manner in embryos; embryos die at 3 dpf upon tissue-wide overexpression of EGFP-HRAS-G12V using hsp70:Gal4 as an activator, whereas embryos with stochastic activation of EGFP-HRAS-G12V are healthy. White arrowheads indicate embryos that are transgenic for both alleles (the driver and effector alleles), other embryos carried neither of the alleles, or only one of them. (B) Lateral (top images) and dorsal (bottom images) view of a larvae (5 dpf) with stochastic activation of EGFP-HRAS-G12V. Hyperpigmentation (white arrowheads) and tumor formation (black arrowheads) are indicated. Right panels are enlarged images of the areas indicated by the black arrowheads. Brightfield, EGFP and merged channels are displayed.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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