ZFIN ID: ZDB-FIG-140728-9
Mathews et al., 2014 - Mutation of 3-hydroxy-3-methylglutaryl CoA synthase I reveals requirements for isoprenoid and cholesterol synthesis in oligodendrocyte migration arrest, axon wrapping, and myelin gene expression. The Journal of neuroscience : the official journal of the Society for Neuroscience   34:3402-12 Full text @ J. Neurosci.
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Gene:
Antibody:
Fish:
Conditions:
Anatomical Terms:
Stage: Protruding-mouth
PHENOTYPE:
Fish:
Conditions:
Observed In:
Stage: Protruding-mouth

Fig. 8 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
EGFP co18Tg; co19Tg control Protruding-mouth dorsal longitudinal fasciculus myelin sheath IFL
Protruding-mouth spinal cord oligodendrocyte IFL
co18Tg; co19Tg chemical treatment: Ro 48-8071 Protruding-mouth spinal cord oligodendrocyte IFL
hmgcs1vu57/vu57; vu16Tg control Protruding-mouth spinal cord oligodendrocyte IFL
Protruding-mouth spinal cord oligodendrocyte IHC
hmgcs1vu57/vu57; vu16Tg chemical treatment: cholesterol Protruding-mouth dorsal longitudinal fasciculus myelin sheath IHC
Protruding-mouth dorsal longitudinal fasciculus myelin sheath IFL
Protruding-mouth spinal cord oligodendrocyte IHC
Protruding-mouth spinal cord oligodendrocyte IFL
vu16Tg control Protruding-mouth dorsal longitudinal fasciculus myelin sheath IHC
Protruding-mouth dorsal longitudinal fasciculus myelin sheath IFL
Protruding-mouth spinal cord oligodendrocyte IHC
Protruding-mouth spinal cord oligodendrocyte IFL
vu16Tg chemical treatment: Ro 48-8071 Protruding-mouth spinal cord oligodendrocyte IFL
Antibody Labeling Details
Antibody Assay Fish Conditions Stage Anatomy
Ab1-tuba IHC hmgcs1vu57/vu57; vu16Tg control Protruding-mouth dorsal longitudinal fasciculus axon
IHC hmgcs1vu57/vu57; vu16Tg chemical treatment: cholesterol Protruding-mouth dorsal longitudinal fasciculus axon
IHC vu16Tg control Protruding-mouth dorsal longitudinal fasciculus axon
Phenotype Details
Fish Conditions Stage Phenotype
co18Tg; co19Tg chemical treatment: Ro 48-8071 Protruding-mouth dorsal longitudinal fasciculus axon ensheathment in central nervous system decreased process quality, abnormal
hmgcs1vu57/vu57; vu16Tg control Protruding-mouth dorsal longitudinal fasciculus axon ensheathment in central nervous system decreased process quality, abnormal
hmgcs1vu57/vu57; vu16Tg chemical treatment: cholesterol Protruding-mouth dorsal longitudinal fasciculus axon ensheathment in central nervous system process quality, normal
vu16Tg chemical treatment: Ro 48-8071 Protruding-mouth dorsal longitudinal fasciculus axon ensheathment in central nervous system decreased process quality, abnormal
Full text @ J. Neurosci.