FIGURE

Fig. 3

ID

ZDB-FIG-140702-37

Publication

Clay et al., 2014 - Cadherin 6 promotes neural crest cell detachment via F-actin regulation and influences active Rho distribution during epithelial-to-mesenchymal transition

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Fig. 3

Cdh6 knockdown reduces NCC detachment and EMT. (A) NCC EMT behaviors and imaging region. (B-D) Time-lapse images (dorsal views, anterior left, confocal z-projections, beginning at 14hpf) of NCCs expressing GFP-CAAX. First frames show a single DIC plane for reference. Yellow dashed lines mark basal neuroepithelial surfaces and white dashed lines mark apical midlines. (B) Control morpholino (controlMO) injection does not affect NCC behaviors or EMT. (C,D) Cdh6 knockdown with cdh6SplMO (B) or cdh6ATGMO (C) disrupts apical detachment and EMT. However, NCCs do exhibit blebbing (arrowheads). Time=h:min:s. Scale bars: 10 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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