FIGURE

Fig. 2

ID

ZDB-FIG-140527-18

Publication

Chen et al., 2014 - Glycogen synthase kinase 3 inhibitors induce the canonical WNT/β-catenin pathway to suppress growth and self-renewal in embryonal rhabdomyosarcoma

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Fig. 2

A secondary screen identifies lead compounds that suppress ERMS tumor growth in live zebrafish. (A) Schematic of the secondary screen completed in zebrafish transplanted with fluorescent-labeled ERMS. (B–G) Pretreatment images for DMSO (B), sunitinib (C), and BIO (D), with corresponding posttreatment images (E, F, and G, respectively). Tumor volume is indicated by the heat map (Right). (Scale bar, 2 mm.) (H) Summary of tumor volume changes in animals treated with compounds that inhibit RAS-signaling in embryonic zebrafish (blue), representative compounds of major classes of hits identified in the human differentiation screen (yellow), or common hits from both screens (green). Error bars equal SD. *Statistical significance by Student t test, with P < 0.05.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA