FIGURE

Fig. 7

ID

ZDB-FIG-140417-26

Publication

Bhatia et al., 2014 - A survey of ancient conserved non-coding elements in the PAX6 locus reveals a landscape of interdigitated cis-regulatory archipelagos

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Fig. 7

Multiple CNEs with overlapping expression patterns form enhancer archipelagos at the PAX6 locus. (A) Overview of the locus with newly characterised agCNEs depicted as ellipses. CNEs with overlapping regulatory activities found in this study are indicated with matching colours. (B) Overlap in the expression patterns of the agCNE1 and E180B enhancers is shown by dual-fluorescence in double transgenic zebrafish at 24 hpf, 48 hpf and 72 dpf. (C) Schematic depiction of the inter-digitated co-existence of multiple regulatory archipelagos at the PAX6 genomic locus. Selected archipelagos are activated in a tissue-specific manner by the binding of TFs and cofactors at defined CNEs.

Expression Data

Genes:	EGFP mCherry
Fish:	zf462Tg; zf466Tg
Anatomical Terms:	spinal cord CNS neuron (sensu Vertebrata) trigeminal ganglion
Stage Range:	Long-pec to Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 387(2), Bhatia, S., Monahan, J., Ravi, V., Gautier, P., Murdoch, E., Brenner, S., van Heyningen, V., Venkatesh, B., and Kleinjan, D.A., A survey of ancient conserved non-coding elements in the PAX6 locus reveals a landscape of interdigitated cis-regulatory archipelagos, 214-228, Copyright (2014) with permission from Elsevier. Full text @ Dev. Biol.