FIGURE

Fig. 2

ID

ZDB-FIG-140311-30

Publication

Gebruers et al., 2013 - A Phenotypic Screen in Zebrafish Identifies a Novel Small-Molecule Inducer of Ectopic Tail Formation Suggestive of Alterations in Non-Canonical Wnt/PCP Signaling

Other Figures

All Figure Page

Back to All Figure Page

Fig. 2

Phenotypic characterization of pCAME-treated embryos.

(A) Embryo treated with 100 μg/mL crude methanolic extract of J. gilgianum. Black arrow denotes ectopic tail. Unless otherwise noted, all treatments were performed at 2- to 4-cell stages. (B) Embryo treated with 140 μM pCAME pulsed 1h at tailbud stage, black arrow denotes ectopic tail; (C) pCAME-treated embryo with 28 μM and with (D) 14 μM pCAME; (E) Embryo treated with 28 μM pCAME; black arrows denote 2 hearts; (F) cmlc2:eGFP embryo treated with 28 μM pCAME; (H) Embryo treated with 28 μM pCAME; black double arrow indicates synophthalmia; (G) and (I) Vehicle-treated control (1% DMSO), black double arrow denotes normal distance between eyes. All embryos are at 48 hpf. The main phenotypic characteristics of pCAME-treated embryos are: tail duplication, AP-axis shortening, absence of pectoral fins, decrease in pigmentation, body curvature, synophthalmia and cardia bifida.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS One