FIGURE

Fig. 5

ID

ZDB-FIG-140307-40

Publication

Haddon et al., 1998 - Delta-Notch signaling and the patterning of sensory cell differentiation in the zebrafish ear: evidence from the mind bomb mutant

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Fig. 5

Wild-type and mib ears compared. (A,B) Lateral views of live embryos (Nomarski optics) at 60 hpf. Note that the ears are smaller and deformed in mib and that the otoliths are drastically reduced, reflecting a deficit in the sensory patches. (C-D) Semi-thin Araldite sections stained with toluidine blue, showing the altered pattern of cell differentiation. (E-H) Confocal images of whole-mount specimens stained with fluorescent phalloidin (green) to reveal actin-rich hair bundles and with 7AAD (red nuclear staining) as a counterstain. (E,F) Optical sections passing transversely through sensory patches; (G,H) En-face views of sensory patches. Supporting cells are missing in mib, while hair cells are present in great excess. (I,J) Stages in the extrusion of hair cells from the otic epithelium in mib; staining is as in E-H. The hair cells eventually degenerate and disappear. hc, hair cell; sc, supporting cell; o, otolith; hb, hair bundle; n, neuron.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mib1^ta52b/ta52b
Observed In:	auditory epithelial support cell hair cell anterior macula hair cell posterior macula lapillus otolith development sagitta
Stage Range:	Prim-15 to Pec-fin

Phenotype Detail

Acknowledgments

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