FIGURE

Fig. 4

ID

ZDB-FIG-131220-45

Publication

Chen et al., 2013 - Cross-species array comparative genomic hybridization identifies novel oncogenic events in zebrafish and human embryonal rhabdomyosarcoma

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Fig. 4

Figure 4. Knockdown of PLXNA1 impairs migration of human ERMS cells.

Representative images of ERMS cells transfected with gene-specific siRNAs at 0 hr (A, control siRNA; C, CCND2 siRNA; E, HOXC6 siRNA; G, PLXNA1 siRNA) and 22 hrs (B, control siRNA; D, CCND2 siRNA; F, HOXC6 siRNA; H, PLXNA1 siRNA) following gap creation. Scale bar indicates 100 µm. (I) Quantification of data from wound healing assay. Each error bar indicates standard deviation across 5–6 independent replicates. (J) A Transwell migration assay was performed in RD cells that stably express either a control shRNA or two independent PLXNA1 shRNAs. Migration was assessed after 24 hours. Each error bar indicates standard deviation across six fields at 200× magnification. Asterisks denote p<0. 05.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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