FIGURE

Fig. 4

ID

ZDB-FIG-131218-8

Publication

Wang et al., 2013 - Fibronectin is deposited by injury-activated epicardial cells and is necessary for zebrafish heart regeneration

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Fig. 4

The Fibronectin partner integrin β3 is expressed during heart regeneration. (A and B) itgb3 expression by in situ hybridization in uninjured (A) and 7 dpa (B) ventricles. (C) Visualization of embryonic itgb3:EGFP-expressing cells (green). Boxed areas indicates a higher magnification view of the heart (area 1), pectoral fin (area 2) and posterior fin fold (area 3). (D and E) Visualization of itgb3:EGFP+ cells (green) in uninjured (D) and 7 dpa (E) ventricles. Insets: high magnification of the boxed area. Blue arrows indicate EGFP-positive cells. Yellow arrows indicate EGFP and MHC double-positive cells, indicative of cardiomyocytes. Dashed line indicates approximate resection plane. Scale bars: 50 μm.

Expression Data

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Antibody Labeling

Phenotype Data

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Acknowledgments

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Reprinted from Developmental Biology, 382(2), Wang, J., Karra, R., Dickson, A.L., and Poss, K.D., Fibronectin is deposited by injury-activated epicardial cells and is necessary for zebrafish heart regeneration, 427-435, Copyright (2013) with permission from Elsevier. Full text @ Dev. Biol.