Community Action Needed: Please respond to the NIH RFI
ZFIN ID: ZDB-FIG-130801-37
Cunningham et al., 2013 - Antagonism between Retinoic Acid and Fibroblast Growth Factor Signaling during Limb Development. Cell Reports   3(5):1503-11 Full text @ Cell Rep.
Observed In:
Stage: Protruding-mouth

Fig. 6 RA-FGF Antagonism Is Required to Generate the Forelimb Field (A) Assessment of forelimb field Tbx5 expression (f) in control versus FGF8-treated wild-type (WT) embryos cultured in vitro for 12 hr. Heart Tbx5 mRNA (h) and somite Uncx4.1 mRNA (s) are also indicated. (B) Rescue of missing pectoral fins in raldh2 (nls) mutant zebrafish by crossing to heat-shock-inducible dn-fgfr1 transgenic fish (heat shock at 37°C; 8–10 hpf). Arrows indicate pectoral fins. See also Figure S6.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
aldh1a2i26/i26 heat shock Protruding-mouth pectoral fin absent, abnormal
aldh1a2i26/i26; pd1Tg heat shock Protruding-mouth pectoral fin present, normal
ZFIN wishes to thank the journal Cell Reports for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Cell Rep.