FIGURE

Fig. S2

ID

ZDB-FIG-130726-11

Publication

Kolpa et al., 2013 - miR-21 represses Pdcd4 during cardiac valvulogenesis

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Fig. S2

Rescue of miR-21 phenotypes. (A) The miR-21 MO AVC defect is rescued by co-injecting mature miR-21 RNA into embryos. *P=6×10^–12. (B) The PDCD4 target protector (TP) MO AVC defect is rescued by co-injecting a splice-acceptor PDCD4 MO. *P=5×10–⁸. (C) The miR-21 MO AVC defect is rescued by co-injecting a splice-acceptor PDCD4 MO into embryos. *P=0.0005. (DF) Representative embryos demonstrating recovery of in situ expression patterns of the indicated genes after the rescue experiments performed above. The AVC is indicated by white arrowheads. (G) Representative embryonic heart demonstrating recovery of AV constriction and looping after the rescue experiments performed above.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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