FIGURE

Fig. 4

ID

ZDB-FIG-130103-24

Publication

Bonner et al., 2012 - Midline crossing is not required for subsequent pathfinding decisions in commissural neurons

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Fig. 4

robo2 and robo3 are required for commissure formation. A-B Confocal microscopic images of WT and ast^-/- commissures from individual CoPA axons (lateral view). ast^ti272z CoPA axons ascend in the midline while WT CoPA axons cross immediately. Anterior is to the left, dorsal is up. Gray dotted line indicates ventral midline of spinal cord. C Measurements of axon length within the midline of the spinal cord, in the anteroposterior axis (arbitrary units) in wild-type, ast^ti272z, and twt embryos. ast^ti272z commissure length is 36 � 3.2 (n = 7), which is 2.8 times that of wild type, which measures 13.3 � 1.1 (n = 19) . In affected twt^tx209embryos, the average length is roughly 15 times that of WT (204 � 22.9; n = 9).

Expression Data

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Antibody Labeling

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Acknowledgments

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