FIGURE

Fig. 2

ID

ZDB-FIG-121210-11

Publication

Littleton et al., 2012 - Whole Plant Based Treatment of Hypercholesterolemia with Crataegus laevigata in a Zebrafish Model

Other Figures

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Fig. 2

Hawthorn Leaves and Flowers (HLF) Decrease BODIPY-cholesterol fluorescence in 4%HCD-fed fish. A. Representative images of the vasculature of fish in 4%HCD and 4%HCD + HLF treated fish. Orange vasculature from TG(Kdrl:mCherry)/Casper line. Green is intravascular BOD-CH fluorescence B. Fluorescence output comparison between groups. Analyzed relative to mean of 4% HCD group having a value of 1. Significant difference between HLF and 4%HCD treated fish. * P < 0.05, bars are mean ± S.D. 1-way ANOVA, Holm-Sidak post-hoc multiple comparison. n = 15-17 per group. C. Comparison of percent uptake between untreated (control), CH-treated, and CH + HLF-treated diets. Five in each experimental group, with the experiment repeated 3x, showed similar uptake (P = 0.925, bars are mean ± S.D. of repeated experiments. 1-way ANOVA). D. Representative Images of BOD-CH treated and BOD-CH + Ezetimibe treated fish (4 dpf). E. Ezetimibe treatment decreases intravascular BOD-CH fluorescence (* P < 0.05, bars are mean ± S.D. 1-way ANOVA, Holm-Sidak post-hoc multiple comparison. n = 13-14 per group).

Expression Data

Gene:	mCherry
Fish:	mitfa^w2/w2; mpv17^a9/a9; s916Tg
Condition:	chemical treatment: pharmaceutical
Anatomical Term:	vasculature
Stage:	Days 21-29

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ BMC Complement. Altern. Med.