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ZDB-FIG-121205-2

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Nesan et al., 2012 - Embryo exposure to elevated cortisol level leads to cardiac performance dysfunction in zebrafish

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Fig. 3

Heart deformity phenotypes. One-cell stage embryos were microinjected with either vehicle (control) or cortisol (32 pg/embryo) and imaged at 48 hpf for morphological deformities. Unaffected embryos (first row) were indistinguishable from wild-type embryos. Mild embryos (second row) displayed pericardial edema only (see arrow); moderate embryos (third row) displayed pericardial edema and malformed heart structures (see arrows); severe embryos (fourth row) exhibited a ruptured pericardium (see arrows) and no heartbeat was visible. Percent phenotype from multiple trials are shown as mean ± standard error of mean (SEM) (control: n = 16 trials of 37–120 embryos; cortisol: n = 14 trials of 53–184 embryos); N.D. – not detectable; indicates significant difference (Student’s t-test, p < 0.05).

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Reprinted from Molecular and Cellular Endocrinology, 363(1-2), Nesan, D., and Vijayan, M.M., Embryo exposure to elevated cortisol level leads to cardiac performance dysfunction in zebrafish, 85-91, Copyright (2012) with permission from Elsevier. Full text @ Mol. Cell. Endocrinol.