FIGURE

Fig. 3

ID

ZDB-FIG-121130-34

Publication

Baxendale et al., 2012 - Identification of compounds with novel anti-convulsant properties in a zebrafish model of epileptic seizures

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Fig. 3

Increased expression of CNS-specific genes accompanies transcriptional activation of fos by pentylenetetrazole. Exposure of 50 hpf embryos to 20 mM PTZ induced expression of genes encoding the transcription factor Npas4 and the secreted neurotrophic factor Bdnf in the ventral forebrain, both of which are known to be synaptic-activity-regulated, within 90 minutes of exposure. Expression of fos in the CNS was strongest in the regions of the forebrain that also expressed npas4 and bdnf. Increased expression of pyya, encoding a homologue of Neuropeptide Y, was also observed at multiple locations within the CNS, most prominently within the posterior hindbrain. Left panels, embryos incubated in E3 medium only; right panels, embryos incubated in E3 medium containing 20 mM PTZ for 90 minutes.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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