FIGURE

Fig. S5

ID

ZDB-FIG-121101-32

Publication

Cox et al., 2012 - An essential role of variant histone h3.3 for ectomesenchyme potential of the cranial neural crest

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Fig. S5

h3f3a^db1092 embryos lack CNC ectomesenchyme but have normal neural patterning. a, In wild-type embryos at 15.5 hpf, expression of dlx2a (blue) marks a subset of the forebrain (FB) and three streams of migrating CNC-derived ectomesenchyme (1–3). In red, pax2a expression marks the mid-hindbrain boundary (MHB) and egr2b expression marks rhombomeres 3 and 5 (R3 and R5) of the hindbrain. b, c, dlx2a-positive ectomesenchyme is reduced (n = 18/18) in h3f3a^db1092/+ heterozygous embryos and completely lost (n = 3/9) or greatly reduced (n = 6/9) in h3f3a^db1092 homozygotes at similar stages. Neural patterning was never affected in h3f3a^db1092 heterozygotes and homozygotes. Scale bar = 100 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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